The Clinical Observation of Inflammation Theory for Depression:The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)
- Author:
Shu-Tsen LIU
1
;
Sheng-Che LIN
;
Jane Pei-Chen CHANG
;
Kai-Jie YANG
;
Che-Sheng CHU
;
Chia-Chun YANG
;
Chih-Sung LIANG
;
Ching-Fang SUN
;
Shao-Cheng WANG
;
Senthil Kumaran SATYANARAYANAN
;
Kuan-Pin SU
Author Information
- Publication Type:Review
- From:Clinical Psychopharmacology and Neuroscience 2023;21(1):10-18
- CountryRepublic of Korea
- Language:English
- Abstract: There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
