Two Cases of Graft-Verwuw-Host Disease(GVHD) Manifested with Vitiligo-like Skin Lesions.
- Author:
Won Sik PYO
;
Young Ho WON
;
Seong Jin KIM
;
Seung Chul LEE
- Publication Type:Case Report
- Keywords:
Graft-versus-host disease ( GVHD);
Vitiligo
- MeSH:
Anemia, Aplastic;
Bone Marrow;
Dermis;
Epidermis;
Lymphocytes;
Melanocytes;
Skin*;
T-Lymphocytes;
Vitiligo
- From:Korean Journal of Dermatology
1999;37(6):756-760
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The skin is a frequently involved organ in graft-versus-host disease(GVHD). Various skin lesions including erythematous eruption, bullae, desquamation, lichenoid, and sclerodermoid lesions have been reported in GVHD, but vitiligo-like lesions were. We present two cases of chronic GVHD presenting multiple hypopigmented patches following allogenic bone marrow transplant(BMT) due to severe aplastic anemia. The histopathologic studies showed focal vacuolar degeneration of basal cells, absence of melanocytes in the epidermis, and perivascular lymphocytic infiltration consisting of T cells in the upper dermis, These cases suggest that vitiligo-like lesions may develop due to marked melanocyte- lymphocyte interaction after BMT.
