A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer
- Author:
Tadayuki TAKAGI
1
;
Mitsuru SUGIMOTO
;
Hidemichi IMAMURA
;
Yosuke TAKAHATA
;
Yuki NAKAJIMA
;
Rei SUZUKI
;
Naoki KONNO
;
Hiroyuki ASAMA
;
Yuki SATO
;
Hiroki IRIE
;
Jun NAKAMURA
;
Mika TAKASUMI
;
Minami HASHIMOTO
;
Tsunetaka KATO
;
Ryoichiro KOBASHI
;
Yuko HASHIMOTO
;
Goro SHIBUKAWA
;
Shigeru MARUBASHI
;
Takuto HIKICHI
;
Hiromasa OHIRA
Author Information
- Publication Type:Original Article
- From:Clinical Endoscopy 2023;56(1):107-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC.
Methods:A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA.
Results:No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation.
Conclusions:EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
