A Case of Dermatofibroma with Granular Cells.
- Author:
Hi Jung KIM
;
Il Yeong SON
;
Eil Soo LEE
;
Kwang Hyun JO
;
Kwang Young PARK
- Publication Type:Case Report
- Keywords:
Dermatofibroma;
Granular cell;
Immunohistochemical staining
- MeSH:
Adult;
Biopsy;
Cell Proliferation;
Cytoplasm;
Histiocytes;
Histiocytoma, Benign Fibrous*;
Humans;
Leg;
Male;
Pruritus;
Sensation
- From:Korean Journal of Dermatology
1999;37(6):761-764
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dermatofibroma with granular cells is composed mainly of spindle shaped cells mixed with in-conspicuous foamy cells that contain granular cytoplasm. We present a case of dermatofibroma with granular cells in a 36-year-old male who visited our clinic to evaluate a slow-growing nodule on the medial side of the left lawer leg. He have had the nodule for five years and sometimes felt an itching sensation. Biopsy of the nodule identified a dermal nodular tumor showing cellular spindle cell proliferation admixed with peripheral foamy histiocytes. With the immunohistochemical staining, the granular cell was positive for alpha-1-antitrypsin and CD68, and negative for S-100. A few electron-dense granules were seen in the cytoplasm on the electronmicroscopic study. These results suggested that the granular cells originated from histiocytes.
