A Case of Subcutaneous Sweet's Syndrome in MYelodysplastic Syndrome Showing Nuelear Segmentation Anomalies of Neutrophils.
- Author:
Young Min JEON
;
Jee Youn WON
;
Chun Hee LEE
;
Min Chul KIM
;
Seok Jong LEE
;
Eun Sup SONG
- Publication Type:Case Report
- Keywords:
Subcutaneous Sweet's syndrome;
Sweet's panniculitis;
Myelodysplastic syndrome;
Nuclear segmenatation anomalies of neutrophils
- MeSH:
Biopsy;
Dermis;
Female;
Humans;
Leg;
Middle Aged;
Myelodysplastic Syndromes*;
Neutrophils*;
Panniculitis;
Skin;
Sweet Syndrome*
- From:Korean Journal of Dermatology
1999;37(6):765-769
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We encountered a case of Sweet's syndrome associated with myelodysplastic syndrome in a 60-year-old woman. The clinical presentation strongly suggested Sweet's syndrome. A skin biopsy specimen taken from her skin lesion on the leg showed an infiltration of numerous neutrophils in the subcutis instead of the dermis which is the main area of neutrophilic infiltration in Sweet's syndrome. Among infiltrating cells, many neutrophils(8%) showed nuclear segmentation anomalies, that is, hyposegmentation(pseudo-Pelger-Huet anomaly) or hypersegmentation. Peripheral blood neutrophils had similar anomalies. This subcutaneous variant of Sweet's syndrome, Sweet's panniculitis, is rare and nuclear segmentation anomalies of neutrophils are probably a good clue to underlying myelodysplastic syndrome.
