A Case of Darier's Disease Improved with Oral Etretinate and Isotretinoin, and CO2 Laser Vaporization.
- Author:
Min Ja JUNG
1
;
Sang Jun LEE
;
Yoon Whoa CHO
;
Jee Yoon HAN
;
Kye Yong SONG
Author Information
1. Department of Dermatology, Korea Veterans Hospital.
- Publication Type:Case Report
- Keywords:
Darier's disease;
Etretinate;
Isotretinoin;
CO2 laser vaporization
- MeSH:
Acitretin*;
Axilla;
Darier Disease*;
Epidermis;
Etretinate*;
Fingers;
Forehead;
Groin;
Humans;
Isotretinoin*;
Lasers, Gas*;
Male;
Middle Aged;
Pruritus;
Scalp;
Sensation;
Volatilization*
- From:Korean Journal of Dermatology
1999;37(6):775-780
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of Darier's disease with typical cutaneous and nail lesions in a 50-year-old male patient. He has brownish hyperkeratotic papules on the ant.chest, back, both axilla and groins and verrucous surfaced hypertrophic plaques on the scalp, forehead and both postauricular areas, which were accompanied by a severe itching sensation and malodor. Also he has finger nail lesions such as subungual hyperkeratotic papules, distal wedge shaped notching and multiple longitudinal red lines on the nail plates. Histopathologic features taken from the inguinal area revealed hyperkeratosis, suprabasal clefts and lacuna, protruded villi lined with one layer of basal cells into the cavity and dyskeratotic cells such as corps ronds in the epidermis. Hyperkeratotic papules on the ant.chest, back, both axilla and groins disappeared after systemic treatment withe a low dose of oral etretinate but hypertrophic plaques on the scalp and both postauricular areas still remained clinically and histopathologically. We then the treated postauricular hypertrophic plaques with CO2 laser vaporization and severe malodor with oral isotretinoin and it resulted in a marked improvement.
