Structural Insights for β-Lactam Antibiotics
10.4062/biomolther.2023.008
- Author:
Dogyeoung KIM
1
;
Sumin KIM
;
Yongdae KWON
;
Yeseul KIM
;
Hyunjae PARK
;
Kiwoong KWAK
;
Hyeonmin LEE
;
Jung Hun LEE
;
Kyung-Min JANG
;
Donghak KIM
;
Sang Hee LEE
;
Lin-Woo KANG
Author Information
1. Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2023;31(2):141-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.
