Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis.
10.3349/ymj.1992.33.4.309
- Author:
Woo Ick YANG
1
Author Information
1. Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Langerhans cell histiocytosis;
antigenic phenotype;
myeloid/macrophage antigens
- MeSH:
Adolescent;
Adult;
Antigens/*genetics;
Child;
Child, Preschool;
Female;
Histiocytosis, Langerhans-Cell/*immunology/pathology;
Human;
Immunohistochemistry/methods;
Infant;
Male;
Middle Age;
Phenotype;
Staining and Labeling;
Support, Non-U.S. Gov't
- From:Yonsei Medical Journal
1992;33(4):309-319
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immunohistochemical study on 26 cases of Langerhans cell histiocytosis (LCH) using several leukocyte antibodies in addition to traditionally used markers (S-100 protein and peanut agglutinin) revealed that the proliferating cells of LCH expressed UCHL1, MT1 as well as classically known positivity for S-100 protein, HLA-DR and peanut agglutinin but were negative for OPD4. In comparison to S-100 protein peanut agglutinin (PNA) using a two stage method produced weaker staining and positively stained cells were sparse. Also in this study, a small proportion of proliferating cells in LCH was observed to be reactive for both myeloid/macrophage antigens (KPI, MAC 387 and lysozyme) and Langerhans cell marker (S-100 protein), verifying the existence of a hybrid form of histiocytes.
