Electron microscopic study of the cases of minimal change nephrotic syndrome with mesangial IgA deposition.
10.3349/ymj.1992.33.4.351
- Author:
Hyeon Joo JEONG
1
;
Soon Hee JUNG
;
In Joon CHOI
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Minimal change nephrotic syndrome;
mesangial IgA deposit;
electron microscopy
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
Female;
Glomerular Mesangium/*metabolism;
Human;
Immunoglobulin A/*metabolism
- From:Yonsei Medical Journal
1992;33(4):351-356
- CountryRepublic of Korea
- Language:English
-
Abstract:
Twenty-five cases of minimal change nephrotic syndrome(minimal change disease, MCD) with mesangial IgA deposition were evaluated electron microscopically. The thickness of the glomerular basement membrane(GBM) was 3875 +/- 1271 A and 3056 +/- 1201 A in adults and children, respectively. Alteration of the GBM was noted in 3 adults and eight children: splitting in 4, focal thinning in one, widening of the lamina rara interna in 10, and widening of the lamina rara externa in 4 cases. Minimal mesangial electron dense deposits were found in all but one adult, and an increase of the mesangial matrix and minimal mesangial proliferation were observed in 8 and 6 cases, respectively. Electron microscopic findings show representative findings of MCD in our cases. A relationship between the GBM alterations in these cases and frequent association of hematuria is suggested and discussed.
