Thyrotropin-secreting pituitary microadenoma.
10.3349/ymj.1992.33.4.368
- Author:
Eun Jig LEE
1
;
Kyung Rae KIM
;
Kyung Mi LEE
;
Doe Heum YOON
;
Young Soo KIM
;
Dong Ik KIM
;
Woo He JUNG
;
Yoon Sok CHUNG
;
Sung Kil LIM
;
Hyun Chul LEE
;
Kap Bum HUH
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
TSH secreting pituitary microadenoma;
alpha-subunit
- MeSH:
Adenoma/diagnosis/pathology/*secretion;
Case Report;
Human;
Magnetic Resonance Imaging;
Male;
Middle Age;
Pituitary Neoplasms/diagnosis/pathology/*secretion;
Thyrotropin/*secretion
- From:Yonsei Medical Journal
1992;33(4):368-373
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present a 45-yr-old male with clinical signs and symptoms of mild hyperthyroidism, high serum levels of T3, T4, and FT4 as well as serum TSH concentration. The elevated alpha-subunit level and alpha-subunit/TSH molar ratio were also observed. These findings indicated the presence of hyperthyroidism due to inappropriate secretion of TSH, whose neoplastic origin was documented by nuclear magnetic resonance scan showing a 0. 6 cm pituitary adenoma. Selective pituitary adenomectomy was completely successful; alpha-subunit, TSH, T3, T 4, and FT4 normalized, and euthyroidism was restored. Light microscopic immunohistochemistry showed that the adenoma was composed of TSH-secreting cells
