Use of Hachimijiogan in Treatment for Cold/Pain Allows Gradual Dose Reduction of Antihypertensives
- VernacularTitle:冷え・痛みの治療に伴う八味地黄丸の緩やかな降圧薬減量効果
- Author:
Takahiko ONO
1
;
Daisuke SUZUKI
2
;
Genzo YAMAZAKI
1
;
Ayako OSE
1
;
Takeshi YOKOYAMA
1
Author Information
- Keywords: jinkyo; hypertension; pain; coldness; hachimijiogan
- From:Kampo Medicine 2021;72(4):368-376
- CountryJapan
- Language:Japanese
- Abstract: The indications of hachimijiogan formulation include lower limb pain, low back pain, edema, fatigue, coldness, and accompanying symptoms of hypertension. In this study, hachimijiogan was administered to patients who complained of symptoms of coldness, pain, etc., and the subsequent blood pressure was observed. Changes in hachimijiogan, a powder pill formulation of crude drugs, were observed in 12 patients aged 45 years or older, with an average age of 71 years. Various symptoms of jinkyo, blood pressure, and laboratory findings were examined. Coldness and pain improved significantly after 3 months. Of the 9 patients who wanted to take hachimijiogan for more than 9 months, 8 were treated with antihypertensive drugs. Among them, 4 underwent an antihypertensive dose reduction by 9 months, and 3 received angiotensin receptor antagonists, and 1 received a Ca antagonist. The systolic pressure before treatment with hachimijiogan averaged 127 mmHg, and after 9 months it was stable at 128 mmHg despite drug dose reduction. In patients with antihypertensive drugs, the long-term use of hachimijiogan may facilitate dose reduction and protection of the vascular endothelium protection. The usefulness of hachimijiogan in the aging society was suggested.
