The Increased Expression and Diagnostic Usefulness of CD56 Antigen in Paraffin Embedded Plasma Cell Neoplasm.
- Author:
Seok Hyung KIM
1
;
Chan Sik PARK
;
Eun Young CHOI
;
Hyun Wook KANG
;
Seong Hoe PARK
;
Doo Hyun CHUNG
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea, doohyun@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
CD56;
Plasma cell;
Multiple myeloma;
Plasmacytoma;
Immunohistochemistry
- MeSH:
Antigens, CD56*;
Astrocytes;
Diagnosis;
Flow Cytometry;
Humans;
Immunoglobulins;
Immunohistochemistry;
Killer Cells, Natural;
Multiple Myeloma;
Neoplasms, Plasma Cell*;
Neurons;
Paraffin*;
Plasma Cells*;
Plasma*;
Plasmacytoma;
Schwann Cells
- From:Korean Journal of Pathology
2001;35(3):201-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The natural killer cell antigen CD56 (NCAM) is a member of the immunoglobulin superfamily and is expressed on neurons, astrocytes, and Schwann cells. Recently, it has been reported that CD56 expression is detected on plasma cells of multiple myeloma by flow cytometry. METHOD: In this study, to test the diagnostic usefulness of the anti-CD56 antibody for plasma cell neoplasm on paraffin-embedded materials, we performed immunohistochemical staining of samples from 19 patients with plasma cell neoplasms. These cases included 14 cases of multiple myeloma, 3 cases of solitary plasmacytoma of the bone, and two cases of extramedullary plasmacytoma. RESULTS: The neoplastic plasma cells from 68 % of the patients with plasma cell neoplasms expressed CD56 highly. CD56 was expressed in all three cases of solitary plasmacytoma of the bone and one of two extramedullary plasmacytoma, and nine out of 14 multiple myeloma cases. In contrast, reactive plasma cells from the 18 patients with miscellaneous lesions were completely negative for CD56. CONCLUSIONS: CD56 is aberrantly expressed on the neoplastic plasma cells, and it may be used as a useful marker for the diagnosis of plasma cell neoplasms in paraffin-embedded tissues.
