Expression of p27kip1 and Cyclin D1 in Serous Epithelial Ovarian Tumors.
- Author:
Sun Young KWON
1
;
Eun Sook CHANG
;
Kun Young KWON
;
Kwan Kyu PARK
;
Soo Kyung KIM
Author Information
1. Departments of Pathology, Pharmacology and Institute for Medical Science Keimyung University School of Medicine, Taegu 700-712, Korea , patho72@hanmail.net
- Publication Type:Original Article
- Keywords:
p27;
Cyclin D1;
Ovarian neoplasms;
Epithelial
- MeSH:
Classification;
Cyclin D1*;
Cyclin-Dependent Kinase Inhibitor p27;
Cyclins*;
Cystadenocarcinoma, Serous;
Cystadenoma, Serous;
Genes, Tumor Suppressor;
Humans;
Incidence;
Ovarian Neoplasms;
Phosphotransferases;
Prognosis;
Recurrence
- From:Korean Journal of Pathology
2001;35(3):220-225
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: p27kip1 is a member of the Cip/Kip family of the cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Decreased expression of p27kip1 is associated with high histologic grade and poor prognosis in a variety of human tumors. METHODS: Sixty-six cases of serous epithelial ovarian tumors were investigated by immunohistochemical staining for p27kip1, cyclin D1, and Ki-67. Clinicopathologic parameters (WHO classification, histologic grade and FIGO stage) were compared with the incidence of p27kip1, cyclin D1 and Ki-67 protein expression in ovarian serous tumors. RESULTS: Reduced expression of p27kip1 was found more freguently in serous cystadenocarcinoma than in serous cystadenoma and borderline malignancy (p<0.05). The decreased expression of p27kip1 was correlated with a high histologic grade and an advanced FIGO stage. Overexpression of cyclin D1 is associated with borderline malignancy and grade I serous cystadenocarcinoma. An inverse relationship was observed between the p27kip1 protein and the Ki-67 labeling index within serous cystadenocarcinoma, but it was not significant. CONCLUSIONS: Reduced expression of p27kip1 protein plays an important role in the biologically aggressive behavior of serous epithelial ovarian tumors and might represent a useful prognostic marker for predicting the recurrence in primary ovarian tumors.
