The Role of EO% and CRP in Risk Factors Analysis of Young Patients with Transfusion Related Adverse Reactions
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0219
- VernacularTitle:C反应蛋白和嗜酸性粒细胞百分比在青年输血不良反应危险因素分析中的作用
- Author:
Nan LI
1
;
Yi-yu ZHANG
2
;
Shuang-feng XIE
1
;
Yan-ling LI
1
Author Information
1. Department of Blood Transfusion， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510000， China
2. Clinical Laboratory， Shenzhen Pingle Orthopaedic Hospital， Shenzhen 518000， China
- Publication Type:Journal Article
- Keywords:
young people;
adverse transfusion reaction;
EO%;
C reactive protein;
risk factors
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(2):335-341
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo discuss the correlation between young patients’ adverse transfusion reaction and pre-transfusion C reactive protein （CRP） level and EO% （percentage of eosinophils） . MethodsThe observation group was chosen from among sixty-six young patients who experienced transfusion-related adverse events between January 2019 and December 2020. For each patient chosen to be included in the observation group， another patient from the same department， with the same disease and gender， who had been hospitalized in the same month and received the same type of blood product transfusion， but had not experienced any transfusion-related adverse effects， was chosen to be in the control group. We examined and compared their ages， transfusion experiences， allergy backgrounds， EO%， and CRP levels in peripheral blood prior to transfusion. A receiver operating characteristic （ROC） curve was used to examine the diagnostic value of EO% and CRP for transfusion-related adverse events. Simultaneously， a logistic analysis was performed on the risk factors for transfusion-related adverse events. ResultsPre-transfusion CRP was higher in patients with FNHTR in the observation group than it was in patients in the control group； pre-transfusion CRP was also higher in patients with ATR in the observation group than it was in patients in the control group. There were also statistically significant differences between these variables in the percentage of patients with transfusion history and pre-transfusion EO% （ P＜0.05）. For the transfusion of different blood types， there was statistical significance in the occurrence of ATR and FNHTR （ P＜0.05）. For the diagnosis of FNHTR， the CRP area under the ROC curve was 0.889， and the best cut-off value was 18.05 mg/L. For the diagnosis of ATR， the area under the ROC curve was 0.749， and the best cut-off values were 17.60 mg/L. ConclusionPre-transfusion C-reactive protein level is an independent risk factor for FNHTR and ATR in young patients； the predictive value of EO% for adverse blood transfusion reactions is insufficient.
