Clinical significance of Golgi protein 73 in liver cirrhosis and its relationship with radiological parameters
10.13491/j.issn.1004-714X.2022.04.025
- VernacularTitle:高尔基体蛋白73在肝硬化中表达水平的临床意义及与影像学指标的关系
- Author:
Jiana LI
1
,
2
;
Dongxu WANG
3
;
Yulin HU
2
;
Hongbin ZHU
3
Author Information
1. The 983rd Hospital of Chinese PLA Joint Logistics Support Force, Tianjin 300142 China
2. The First Hospital of Jilin University, Changchun 130021 China.
3. The 983rd Hospital of Chinese PLA Joint Logistics Support Force, Tianjin 300142 China.
- Publication Type:OriginalArticles
- Keywords:
Golgi protein 73;
Cirrhosis;
Chronic hepatitis;
Child-Pugh grade
- From:
Chinese Journal of Radiological Health
2022;31(4):512-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of serum Golgi protein 73 (GP73) in liver cirrhosis and its association with radiological parameters. Methods We included 177 patients with liver cirrhosis and 61 patients with chronic hepatitis admitted to The First Hospital of Jilin University from January 2016 to December 2018, with 70 healthy subjects who underwent physical examination during the same period as the control. We compared GP73, alanine transaminase (ALT), aspartate transaminase (AST), albumin (ALB), total bilirubin (TBIL), prothrombin time (PT), and main portal vein diameter between the patients with liver cirrhosis, patients with chronic hepatitis, and healthy subjects. The GP73 level was further compared between liver cirrhosis subgroups by various classification methods. The correlation between GP73 and ALT, AST, ALB, TBIL, PT, and main portal vein diameter was analyzed. Results The GP73 level was significantly higher in the liver cirrhosis group than in the chronic hepatitis group and the healthy control group (P < 0.001). Patients with decompensated cirrhosis had a significantly higher serum GP73 level than those with compensated cirrhosis (P < 0.001). The serum GP73 levels in the Child-Pugh B and C cirrhosis subgroups were significantly higher than that in the Child-Pugh A cirrhosis subgroup (P < 0.05). In the liver cirrhosis group, the GP73 level was positively correlated with AST, ALT, TBIL, PT, and main portal vein diameter, while negatively correlated with ALB. Conclusion Serum GP73 is significantly increased in patients with liver cirrhosis, which is closely related to liver injury indicators. Serum GP73 shows important clinical value for the early diagnosis and prognosis assessment of liver cirrhosis.
