Analysis of the correlation between MRI features and HER-2 expression inductal carcinoma in situ
10.13491/j.issn.1004-714X.2022.04.024
- VernacularTitle:乳腺导管内原位癌的MRI特征与HER-2表达的相关性分析
- Author:
Minmin TENG
1
;
Yuanwei SHAO
1
;
Juanjuan FANG
1
;
Liwei ZHANG
1
;
Tingzhou LIU
1
;
Huafang LI
2
Author Information
1. Dezhou Second People’s Hospital, Medical Imaging Center, Dezhou 253004 China.
2. Pathology Department, Dezhou 253004 China.
- Publication Type:OriginalArticles
- Keywords:
Ductal carcinoma in situ;
MRI;
Human epidermal growth factor receptor-2;
Clumped enhancement
- From:
Chinese Journal of Radiological Health
2022;31(4):507-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the features of multimodal magnetic resonance imaging (MRI) and the expression of human epidermal growth factor receptor-2 (HER-2) in ductal carcinoma in situ (DCIS). Methods A total of 53 patients with DCIS confirmed by surgery and pathology in Dezhou Second People’s Hospital from September 2018 to June 2021 were analyzed retrospectively. The patients were divided into HER-2 positive group (29 cases) and HER-2 negative group (24 cases). MRI features were compared between the two groups. Results There were significant differences in the internal enhancement characteristics, microvascular sign, and time-intensity curve type between the two groups (P < 0.05). There were no significant differences in lesion morphology, non-mass-like enhancement pattern, and apparent diffusion coefficient value (P > 0.05). The HER-2 positive group showed clumped enhancement (65.5%), type Ⅱ (48.1%) andtype Ⅲ (29.6%) time-intensity curves, and microvascular sign (89.7%). The HER-2 negative group showed clusteredring enhancement (50.0%), type Ⅱ (45.8%) and type I (54.2%) time-intensity curves, and microvascular sign (54.2%). A combination of clumped enhancement, microvascular sign, and type Ⅲ time-intensity curve showed 100% specificity and 100% positive predictive value for the diagnosis of HER-2 positive DCIS. Conclusion Clumped enhancement, microvascular sign, and type Ⅱ or Ⅲ time-intensity curve on MRI can largely reflect the expression of HER-2 in DCIS. The three can be used in combination to improve the diagnostic efficiency of HER-2 positive DCIS.
