Analysis on the influencing factors for re-positive nucleic acid test result in discharged COVID-19 patients in Chengdu
- VernacularTitle:成都市新冠出院病例复查核酸阳性的影响因素分析
- Author:
Yi MAO
1
;
Xiaoli TUO
2
,
3
;
Hong CHEN
4
;
Ming YANG
5
;
Renqing ZHANG
1
;
Liangshuang JIANG
1
;
Yong YUE
2
,
3
;
Ping PU
1
;
Liangqian LIU
1
;
Xiaoman JIANG
2
,
3
Author Information
1. Emergency Department, Chengdu Public Health Clinical Medical Center, Chengdu, 610061, P. R. China
2. 2. Chengdu Workstation of Emerging Infectious Diseases, Chinese Academy of Medical Sciences, Chengdu, 610000, P. R. China
3. 3. Chengdu Center for Disease Control and Prevention, Chengdu, 610000, P. R. China
4. Department of Critical Care, Chengdu Public Health Clinical Medical Center, Chengdu, 610061, P. R. China
5. Tuberculosis Department, Chengdu Public Health Clinical Medical Center, Chengdu, 610061, P. R. China
- Publication Type:Journal Article
- Keywords:
Coronavirus disease 2019;
nucleic acid test;
re-positive;
discharged patients;
influencing factors
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(02):173-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors for re-positive nucleic acid test in discharged corona-virus disease 2019 (COVID-19) patients in Chengdu, Sichuan Province, and to provide data support for the epidemics prevention and control. Methods The clinical data of 660 discharged COVID-19 patients from January 23, 2020 to February 28, 2021 in our center were retrospectively analyzed. The patients were divided into two groups according to the reexamination of virus nucleic acid, including a negative group [549 patients, including 428 males and 121 females with a median age of 33.0 (28.0, 48.0) years] and a positive group [111 patients, including 76 males and 35 females with a median age of 39.0 (28.0, 51.0) years]. The clinical data of the two groups were compared. Results The re-positive rate of the discharged patients was 16.82%. Univariate analysis showed that the re-positive rate of females was higher than that of males (χ2=4.608, P=0.032). The re-positive rate of confirmed patients was higher than that of asymptomatic infected patients (χ2=8.140, P=0.004). The re-positive rate of domestic patients was higher than that of imported patients (χ2=9.178, P=0.002). The counts of CD3+ (P=0.038), CD4+ (P=0.048) and CD8+ (P=0.040) T lymphocytes in the negative group were higher than those in the positive group. The binary logistic regression analysis showed that the clinical classification and CD8+ T lymphocyte count were independent risk factors affecting the recurrence of virility. Conclusion The gender, origin, T lymphocyte subsets count and clinical type are the influencing factors for re-positive result, and clinical type and CD8+ T lymphocyte count are the independent influencing factors for re-positive result. Therefore, improving the immunity of infected patients, as well as early detection and timely treatment are effective means to reduce the re-positive occurrence.
