Physiological pharmacokinetic model of children and its application of modeling software

VernacularTitle:儿童生理药代动力学模型及其建模软件的应用
Author: Xu ZHOU ; Yuan-yuan WEI ; Tao MA ; Yue-zhou TANG ; Yun-jie DANG ; De-ying CAO
Publication Type:Research Article
Keywords: rug disposition; prediction; physiology based pharmacokinetic model; pediatric physiologic pharmacokinetic model; modeling software
From: Acta Pharmaceutica Sinica 2023;58(2):320-329
CountryChina
Language:Chinese
Abstract: Developmental changes in children can affect drug disposition and clinical effects. A physiologically-based pharmacokinetic (PBPK) model is a mathematical model that can be used to predict blood drug concentrations in children and gain insight into age-dependent physiological differences in drug disposition impact. Pediatric PBPK (P-PBPK) models have attracted attention over the past decade. With the concerted efforts of academia, pharmaceutical companies, and regulatory agencies, there are more and more examples of pediatric clinical studies using PBPK models. Nevertheless, the number of P-PBPK models and their predictive performance still lag behind adult models. By referring to the literature, we study the process of children adapting to adult absorption, distribution, metabolism, and excretion (ADME) parameters and analyze the general principles of P-PBPK model establishment. In addition, we summarize the functions and application examples of commonly used P-PBPK modeling software to provide a basis for the rational application of modeling software.