A new macrocyclic flavonoid from Onychium japonicum
10.16438/j.0513-4870.2022-1067
- VernacularTitle:野雉尾金粉蕨中一个新的大环黄酮
- Author:
Guang-feng LIAO
;
Liu-yan MO
;
Ming-xue TENG
;
Xiu-hong XU
;
Qian-xi HUANG
;
Ru-mei LU
- Publication Type:Research Article
- Keywords:
italic>Onychium japonicum;
onychone A;
italic>Onychium;
flavonoids;
cytotoxic activity
- From:
Acta Pharmaceutica Sinica
2023;58(2):423-428
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds were isolated from Onychium japonicum by macroporous resin, silica gel, ODS, Sephadex LH-20 column chromatography and semi-preparative HPLC. Their structures were identified by NMR, MS and other spectroscopic methods as onychone A (1), quercetin (2), quercetin-3-O-α-L-rhamnoside (3), kaempferol-7-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnopyranoside (5), (-)-prunin (6), and norathyriol (7). Compound 1 is a novel macrocyclic flavonoid, and all the others are reported from this plant for the first time. In vitro cytotoxic activities of compounds 1-7 were evaluated by MTS testing with five cancer cell lines. Compound 7 exhibited weak cytotoxicity against tumor cell lines A549, SMMC-7721, and SW480.
