Research progress of microparticles in traditional Chinese medicine decoction
10.16438/j.0513-4870.2022-0781
- VernacularTitle:中药汤剂中的微粒研究进展
- Author:
Yu-fang WEI
1
;
Zhi-ying DOU
1
;
Chuan-shan JIN
2
;
Rui-xi LI
1
;
Zi-wen ZHAO
1
;
Ding-ding WANG
1
;
Yu-mei LIU
1
;
Zhuo-er YANG
1
;
Rong-feng HU
2
;
Yu-zhou CHEN
1
Author Information
1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. Anhui Provincial Key Laboratory of Pharmaceutical Technology and Application, Anhui University of Chinese Medicine, Hefei 230012, China
- Publication Type:Research Article
- Keywords:
ecoction;
microparticle;
self-assembly;
physical interaction;
chemical reaction
- From:
Acta Pharmaceutica Sinica
2023;57(2):339-350
- CountryChina
- Language:Chinese
-
Abstract:
Decoction is a classical dosage form of traditional Chinese medicines. In the process of decocting, various complex components produce physical interactions and chemical reactions, among which physical interactions include van der Waals force, hydrogen bond, electrostatic interaction, π-π stacking, etc., and chemical reactions include Maillard reaction, oxidation reaction, hydrolysis reaction, degradation reaction, polymerization reaction, etc. New substances and original ingredients from chemical reactions can be further activated. These effects form the basis of particle formation in the broth. The sizes of the particles in decoctions range from nanoscale to micron scale, mostly composed of polysaccharide, protein matrix, wrapped in water insoluble molecules, can increase the dispersion of insoluble components and the stability of unstable components, as well as reduce the volatile components and toxic components of volatile components, and ultimately achieve the purpose of efficient absorption and toxicity reduction. From the angle of physical change and chemical reaction in the process of decoction, this paper expounds the formation mechanism of particles in decoction, expounds the research method of particles, analyzes the components in particles and the interaction between components, and then explains the pharmacodynamic characteristics of traditional Chinese medicine decoction, which provides the foundation for the modernization of Chinese decoction.
