Application of PDX model in the evaluation of nano-delivery systems
10.16438/j.0513-4870.2022-0720
- VernacularTitle:PDX模型在纳米递送系统评价中的应用
- Author:
Yu-meng XI
1
;
Yu LU
1
;
Xiao-ming HE
1
;
Shao-kun YANG
1
;
Jia ZHANG
2
;
Jian-kai YANG
3
;
Chao-xing HE
1
;
Bai XIANG
1
Author Information
1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
2. The Fourth Hospital of Shijiazhuang, Shijiazhuang 050035, China
3. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
- Publication Type:Research Article
- Keywords:
nano-delivery system;
patient-derived xenografts model;
cancer;
immunodeficient mouse;
rug evaluation
- From:
Acta Pharmaceutica Sinica
2023;58(2):330-338
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is a major disease affecting human health. The nano-delivery system itself has a unique size effect and it can achieve tumor-targeted distribution of drug molecules, improve the therapeutic effect, and reduce the toxic and side effects on normal tissues and cells after functional modification. Patient-derived xenografts (PDX) models can be established by transplanting patient-derived cancer cells or small tumor tissue into immunodeficient mice directly. Compared with the tumor cell line model, this model can preserve the key features of the primary tumor such as histomorphology, heterogeneity, and genetic abnormalities, and keep them stable between generations. PDX models are widely used in drug evaluation, target discovery and biomarker development, especially providing a reliable research platform for the diagnosis and treatment evaluation of nano-delivery systems. This review summarizes the application of several common cancer PDX models in the evaluation of nano-delivery systems, in order to provide references for researchers to perform related research.
