Signaling Pathways Related to Diabetic Peripheral Neuropathy Treated by Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20222439
- VernacularTitle:中医药治疗糖尿病周围神经病变相关信号通路的研究进展
- Author:
Sicheng YAO
1
;
Yu SUN
2
;
Xiwei ZHANG
3
;
Yongju YANG
3
;
Chongmin CHEN
2
;
Xuefeng GUAN
1
Author Information
1. Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110085， China
2. Shenyang Orthopedic Hospital， Shenyang 110044， China
3. The Affiliated Hospital of Liaoning University of TCM， Shenyang 110033， China
- Publication Type:Journal Article
- Keywords:
diabetes;
peripheral neuropathy;
Chinese medicine;
signaling pathways;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(9):261-267
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy （DPN） is one of the common complications of diabetes. The disease has a long course with nerve pain and other symptoms， seriously affecting the quality of life of patients. DPN is related to high glucose in vivo， inflammation， oxidative stress， apoptosis， and autophagy， involving phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， Janus kinase （JAK）/signal transducer and activator of transcription （STAT）， nuclear factor-κB （NF-κB）， mitogen-activated protein kinase （MAPK）， and other signaling pathways. At present， the treatment of DPN mainly focuses on symptomatic treatments such as blood glucose control and neurotrophic therapy， but the effect is not ideal. Therefore， it is particularly important to select a reasonable and effective drug to prevent and treat DPN. In recent years， Chinese medicine has played an important role in the treatment of DPN. Many studies have explored the mechanism of Chinese medicine in the treatment of DPN， and it has been found that some Chinese medicine monomers and compounds can regulate signaling pathways to prevent and treat DPN. This paper reviewed the research results of signaling pathways involved in DPN and the regulation of related pathways by Chinese medicine， aiming to provide references for the clinical treatment of DPN.
