Progress of potential therapeutic targets and small molecule ligands of anti-colorectal cancer pathogenic Fusobacterium nucleatum
10.16438/j.0513-4870.2022-1098
- VernacularTitle:抗结直肠癌致病具核梭杆菌的潜在治疗靶点及其小分子配体
- Author:
Xue-xin BAI
;
Ya-hui HUANG
;
Chun-quan SHENG
;
Shan-chao WU
- Publication Type:Research Article
- Keywords:
italic>Fusobacterium nucleatum;
colorectal cancer;
target;
small molecule ligand
- From:
Acta Pharmaceutica Sinica
2023;58(3):639-645
- CountryChina
- Language:Chinese
-
Abstract:
The composition of intestinal microflora is closely related to the occurrence and development of colorectal cancer (CRC). Among them, Fusobacterium nucleatum (Fn) has been proved directly related to the recurrence, metastasis and chemotherapy resistance of CRC. Therefore, it is of great significance for the prevention and treatment of colorectal cancer by the exploration potential anti-Fn drug targets and discovery small molecule drugs. However, no selective anti-Fn small molecule inhibitors have been reported so far as well as their anti-Fn thereby "anti-Fn further anticancer" mechanisms are unclear. Herein, this article reviews the potential therapeutic targets and small molecule ligands of Fn in order to provide a reference for the development of anti-Fn and anti-CRC small molecule drugs.
