The modulation and mechanisms of high-altitude hypoxia in drug transport across the blood-brain barrier
10.16438/j.0513-4870.2022-1095
- VernacularTitle:高原低氧对药物跨血脑屏障转运的调节作用及机制
- Author:
Gui-qin LIU
1
;
Xue BAI
1
;
Jian-xin YANG
1
;
Ya-bin DUAN
2
;
Jun-bo ZHU
1
;
Lu TIAN
3
;
Xiang-yang LI
1
,
4
Author Information
1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
2. Affiliated Hospital of Qinghai University, Xining 810001, China
3. Medical College of Qinghai University, Xining 810001, China
4. State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China
- Publication Type:Research Article
- Keywords:
blood-brain barrier;
high-altitude hypoxia;
rug transporter;
rug metabolizing enzyme;
rug transport
- From:
Acta Pharmaceutica Sinica
2023;58(3):659-671
- CountryChina
- Language:Chinese
-
Abstract:
The function of the central nervous system was significantly altered under high-altitude hypoxia, and these changes lead to central nervous system disease and affected the metabolism of drugs in vivo. The blood-brain barrier is essential for maintaining central nervous system stability and plays a key role in the regulation of drug metabolism, and barrier structure and dysfunction affect drug transport to the brain. Changes in the structure and function of the blood-brain barrier and the transport of drugs across the blood-brain barrier under high-altitude hypoxia are regulated by changes in brain microvascular endothelial cells, astrocytes and pericytes, and are regulated by drug metabolism factors such as drug transporters and drug metabolizing enzymes. This article reviews the effects of high-altitude hypoxia on the structure and function of the blood-brain barrier and the effects of changes in the blood-brain barrier on drug metabolism. We investigate the regulatory effects and underlying mechanisms of the blood-brain barrier and related pathways such as transcription factors, inflammatory factors and nuclear receptors on drug transport under high-altitude hypoxia.
