Research progress of sphingosine kinase and sphingosine-1-phosphate (S1P) /S1P receptor signaling in tumor microenvironment

VernacularTitle:鞘氨醇激酶和1-磷酸鞘氨醇及其受体信号在肿瘤微环境中的研究进展
Author: Xi-hua WEI ; Ze-qun WANG ; Jing-jing CHEN ; Yan PAN
Publication Type:Research Article
Keywords: tumor microenvironment; sphingosine kinase; sphingosine-1-phosphate; sphingosine 1-phosphate receptor; anti-tumor drug
From: Acta Pharmaceutica Sinica 2023;57(3):571-580
CountryChina
Language:Chinese
Abstract: Sphingosine kinase (SphK), sphingosine-1-phosphate (S1P) and S1P receptor (S1PR) are involved in the tumor biological processes such as tumor cell proliferation and migration, and play an important role in the development of cancer. In recent years, researchers have increasingly focused on the interaction between cancer cells and the tumor microenvironment. The tumor microenvironment is genetically stable and can be induced to an antitumor phenotype, which has significant therapeutic advantages. Studies have shown that SphK/S1P/S1PR can regulate multiple aspects of the tumor microenvironment. This review summarizes the effects of SphK and S1P/S1PR signaling on the tumor microenvironment from four perspectives: tumor immune microenvironment, cancer associated fibroblasts, tumor angiogenesis and tumor hypoxic microenvironment, and also outlines potential drug research related to these signal molecules, aiming to elucidate the role of SphK/S1P/S1PR in tumor occurrence and development and provide new ideas for the research of anti-tumor drugs.