Advance on small molecule self-assembled nano-drug delivery system
10.16438/j.0513-4870.2022-0794
- VernacularTitle:小分子自组装纳米递药系统研究进展
- Author:
Yu-ting LIU
;
Yue-quan WANG
;
Shen-wu ZHANG
;
Cong LUO
- Publication Type:Research Article
- Keywords:
small-molecule drug;
small-molecule prodrug;
self-assembly;
hybrid nanoassembly;
nano-drug delivery system
- From:
Acta Pharmaceutica Sinica
2023;58(3):516-529
- CountryChina
- Language:Chinese
-
Abstract:
Since the application of biomedical nanotechnology in the field of drug delivery breathes new life into the research and development of high-end innovative agents, a substantial number of novel nano-drug delivery systems (nano-DDSs) have been successively developed and applied in the clinical practice. Among them, small molecule pure drug and prodrug-based nanoassemblies have grasped great attention, owing to the facile fabrication, ultrahigh drug loading and feasible industrial production. Herein, we provide an overview on the latest updates of small-molecule nanoassemblies. Firstly, the self-assembled prodrug-based nano-DDSs are introduced, including nanoassemblies formed by amphiphilic monomeric prodrugs, hydrophobic monomeric prodrugs and dimer monomeric prodrugs. Then, the recent advances on nanoassemblies of small molecule pure chemical drugs and biological drugs are presented. Furthermore, carrier-free small-molecule hybrid nanoassemblies of pure drugs and/or prodrugs are summarized and analyzed. Finally, the rational design, application prospects and clinical challenges of small-molecule self-assembled nano-DDSs are discussed and highlighted. This review aims to provide scientific reference for constructing the next generation of nanomedicines.
