Research progress of exosome delivery vehicles in tumor phototherapy

VernacularTitle:外泌体递送载体在肿瘤光学治疗研究进展
Author: Yu-liang YANG ; Zhong-ming HUANG ; Xi-liang LI ; Yu LUO ; Sheng-liang LI
Publication Type:Research Article
Keywords: exosome; elivery system; nanomedicine; neoplasm; photodynamic therapy; photothermal therapy
From: Acta Pharmaceutica Sinica 2023;57(3):506-515
CountryChina
Language:Chinese
Abstract: Exosome is a self-secreted phospholipid bilayer nanovesicles, and has shown great potential in drug delivery field due to the important advantages of low immunogenicity and homologous targeting. Phototherapy, mainly includes photodynamic therapy (PDT) and photothermal therapy (PTT), utilize light to activate photoactive drug for tumor cell killing. The advanced therapeutic strategy shows low toxic side-effect and non-invasion precise advantages, and thus has made great progress in tumor treatment over the past few years. Therefore, using exosomes as a drug delivery system to deliver phototherapeutic agents can improve therapeutic performances with a reduced side-effect, and further enhance their application potential for clinical tumor therapy. This review focus on the rising cross-subjects field involving exosomes and phototherapy, and mainly introduce the research progress and relative case of exosomes-based delivery system for cancer phototherapy. Additionally, the advantages and challenges of exosome-based phototherapy are also discussed and proposed.