Effect of thimerosal on vaccine antigen activity and its mechanism
- VernacularTitle:硫柳汞对疫苗抗原活性的影响及其作用机制
- Author:
ZHANG Xiu⁃li
1
;
ZHANG Zhi⁃gang
;
ZHAO Qin⁃jian
Author Information
- Publication Type:Journal Article
- Keywords: Thimerosal；Protein antigen；Antigenicity；Immunogenicity
- From: Chinese Journal of Biologicals 2023;36(1):119-123
- CountryChina
- Language:Chinese
- Abstract: Abstract： Thimerosal is commonly used as a preservative in biological products，especially in vaccines. Although it has been removed from single ⁃ dose vaccines in most countries，thimerosal is still widely used in multi ⁃ dose vaccines at present. Thimerosal，as a component in vaccine preparation，should be compatible with other components，especially should not damage the activity of antigen. However，in recent years，many studies have reported that thiomersal can reduce the antigenicity and immunogenicity of vaccine antigens，especially protein antigens containing or rich in cysteine（Cys）， suggesting that the effect of thimerosal on vaccine antigen activity should be fully evaluated when it is used as a vaccine preservative. In this paper，the effects of thimerosal on antigenicity and immunogenicity of two inactivated vaccines and three recombinant protein vaccines and the possible mechanisms were reviewed，in order to provide reference for rational selection of vaccine preservatives.
- Full text:硫柳汞对疫苗抗原活性的影响及其作用机制.pdf
