Bioinformatics analysis of sterol O⁃acyltransferase 1 gene related to hepatocellular carcinoma
- VernacularTitle:肝细胞癌相关固醇⁃O酰基转移酶1基因的生物信息学分析
- Author:
CHENG Ri na
1
;
WANG Xiao⁃yu
;
MA Qing
;
KONG Ling⁃hua
;
ZHANG Yu⁃qi
;
QIN Kai⁃li
;
ZHAO Ying⁃zhu
;
SU Dan
;
GONG Tao
;
GUO Rui
Author Information
- Publication Type:Journal Article
- Keywords: Sterol O⁃acyltransferase 1（SOAT1）；Hepatocellular carcinoma；Bioinformatics；Structure；Function
- From: Chinese Journal of Biologicals 2023;36(1):26-31
- CountryChina
- Language:Chinese
- Abstract: Abstract：Objective To predict the structure and function of sterol O⁃acyltransferase 1（SOAT1）related to hepatocellular carcinoma（HCC）by using bioinformatics tools，in order to understand its mechanism as the marker and therapeutic target of S⁃Ⅲ subtype. Methods The structure，function and protein interaction of SOAT1 were predicted and analyzed by using databases or softwares such as NCBI，STRING，Protscale，SignalP，TMHMM，PSORT，SOPMA，SWISS ⁃ MODEL， NetNGlyc，NetOGlyc，Netphos and ProtParam. Results The protein encoded by SOAT1 was a hydrophobic protein with good stability，which was a nonclassical pathway protein with 8 transmembrane regions，mainly distributed among the cell membrane. SOAT1 was expressed in many tissues，while most of them in the adrenal gland，which showed multiple phosphorylation sites and was mainly involved in the synthesis and catabolism of cholesterol. Conclusion Bioinformatics analysis of structure and function of SOAT1 showed that SOAT1 lipid synthesis and catabolism pathways played an important role，and lipid expression was closely related to the development of cancer，indicating that the treatment of HCC may be achieved by regulating the expression of SOAT1 gene.
- Full text:肝细胞癌相关固醇⁃O酰基转移酶1基因的生物信息学分析.pdf
