The role of LXRs in the pathogenesis of Alzheimer's disease: a review

Author: Heqiong LIU ; Chaoying MA ; Huicai GUO ; Lei WANG ; Yi LIU
Publication Type:Journal Article
Keywords: liver X receptor; Alzheimer's disease; cholesterol metabolism; inflammatory response; synapse formation
From: Journal of Preventive Medicine 2023;35(3):215-217
CountryChina
Language:Chinese
Abstract: Abstract:Alzheimer's disease (AD) is a neurodegenerative disease characterized by deposition of β-amyloid (Aβ). Liver X receptors (LXRs), a member of the nuclear receptor transcription factor superfamily, are widely expressed in brain, which may be involved in the development and progression of AD. Based on the international and national publications pertaining to the association between LXRs and AD from 2010 to 2022, this review summarizes the advances on the involvement of LXRs in the regulation of cholesterol metabolism, inflammatory response and synapse formation in the pathogenesis of AD was reviewed, so as to provide insights into the prevention and treatment of AD.
Full text:肝X受体在阿尔茨海默病发病机制中的研究进展.pdf