Correlation of Expressions of P170,TOPⅡ and Proliferation in Gliomas
- VernacularTitle:脑胶质瘤中P170、TOPⅡ表达与其增殖活性关系的研究
- Author:
Shuqing SUN
;
Guilin LI
;
Yujin SU
;
Zuolin XU
;
Yun CUI
;
Jingyi FANG
;
Jingjun LI
- Publication Type:Journal Article
- Keywords:
gliomas, P170, topoisomerase Ⅱ(TOPⅡ), Ki-67
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(4):349-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the expressions of P170,topoisomerase Ⅱ(TOPⅡ)and the proliferation in gliomas.Methods Ki-67 was used as the marker of the proliferation in gliomas.The expressions of P170,TOPⅡ and Ki-67 were tested by S-P immunohistochemical technique using monoclonal antibody to their protein in 54 cases of low-grade gliomas(WHO Ⅰ～Ⅱ grade)and 54 cases of high-grade gliomas(WHO Ⅲ～Ⅳ grade),analysis of the clinical and follow-up were performed.Results The expressions of P170,TOPⅡ and Ki-67 had significant differences between low-grade and high-grade gliomas(P<0.01).Correlation analysis showed that the expression of P170 was negatively related with Ki-67(r=-0.276,P=0.019);the expression of TOPⅡ was positively related with Ki-67(r= 0.637,P<0.001);there was no correlation between the expressions of P170 and TOPⅡ.Conclusion The expressions of P170 and TOPⅡ are associated with the malignant prognosis in gliomas.
