Comparison of bacterial and human drug metabolizing enzymes in database and prospect of influence of intestinal bacteria on drug metabolism
10.11665/j.issn.1000-5048.20220705001
- VernacularTitle:数据库中细菌与人源药物代谢酶的比较及肠道菌群对药物代谢影响的展望
- Author:
Yifan HUANGFU
1
;
Yuye RAN
;
Shuo FENG
;
Jing LI
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
intestinal microbiota;
drug metabolism;
metabolic enzyme;
artificial intelligence
- From:
Journal of China Pharmaceutical University
2023;54(1):122-130
- CountryChina
- Language:Chinese
-
Abstract:
This study focused on various databases and literatures related to drug metabolism, collated and analyzed the information related to bacterial and human drug metabolic enzymes, and compared the similarities and differences between the information included in the database of bacterial and human drug metabolic enzymes. Results found more bacterial drug metabolic enzymes than human drug metabolic enzymes (9 703 vs 964), but much less than the total number of bacterial enzymes in BRENDA database (9 703 vs 20 835 235), indicating that the influence of bacteria on drug metabolism could have been greatly underestimated, and that further systematic research is needed.We summarized the progress and shortcomings of the current research on the influence of intestinal flora on drug metabolism, and proposed a research idea, that is, to predict through artificial intelligence whether intestinal bacterial proteins have the ability to metabolize drugs, to verify their biological functions by in vitro/in vivo experiments and gene editing, and to establish a database of drug metabolic enzymes from intestinal bacteria with complete annotation functions, in an attempt to provide a solid theoretical basis for further exploration of the effects of intestinal flora on drug metabolism.
