Advance in Neuron Axonal Singnals on Ensheathing Glial Cells(review)
- VernacularTitle:神经元轴突因子对成鞘胶质细胞影响的研究进展
- Author:
Nian CAO
;
Limin PENG
;
Liuyang YANG
;
Yunlai LIU
;
Zhongxiang YAO
- Publication Type:Journal Article
- Keywords:
neuron axonal singnals, ensheathing glial cells, myelination, MAPK pathway, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(6):538-540
- CountryChina
- Language:Chinese
-
Abstract:
Neuron axonal signals play an important role in myelination of central nervous system. Myelination depends on a balance between the positive and negative neuron axonal signals. The positive signals, such as neuregulins (NRG), neuron cell adhesion molecule (NCAM), electrical activity and neurotrophins, have a function of promoting the proliferation and the myelination thickness of ensheathing glial cells, while the negative factors like the L1 protein, poly-sialic acid-neuron cell adhesion molecule (PSA-NCAM), will lead a marked decrease in myelination. Here，we mainly present some well-researched neuron axonal factors and their mechanism.
