Effect of Chronic Exercise Training and Enalapril on Renal Function in Thy-1-Crf
- VernacularTitle:长期中等强度运动训练及依那普利对Thy-1肾炎慢性肾功能衰竭大鼠模型肾功能的影响
- Author:
Xuemin WU
;
Yuxiao XIE
;
Qiliang SUN
;
Zhengbo SHANGYUE
;
ZUOTENGDETAILANG
- Publication Type:Journal Article
- Keywords:
exercise training, enalapril, anti-Thy-1 nephritis Wistar rats, renal function
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(6):534-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the renal effects of chronic exercise training and enalapril in uninephrectomized anti-Thy-1 nephritis Wistar rats (Thy-1-Crf). Methods 5-week-old Wistar rats were subjected to uninephrectomy. Anti-Thy-1 nephritis was induced by injecting 200 μg/kg OX-7 intravenously once a week for four times. They were divided into 3 groups: non exercise; moderate exercise with treadmill running(20 m/min, 0 grade-incline for 60 min); moderate exercise with an angiotensin converting enzyme(ACE) inhibitors, enalapril (2 mg/kg/day i.p.) for 8 weeks.Results Exercise did not suppress the increase in proteinuria in Thy-1-Crf. However, enalapril significantly decreased systolic blood pressure(SBP), urinary protein excretion(UpE), and index of glomerular sclerosis (IGS) in Thy-1-Crf. Conclusion The renal protective effects of moderate exercise in models of renal failure differ depending on the etiology of renal failure. It also suggests that enalapril can widen the acceptable range of exercise intensity in Thy-1-Crf.
