Experimental Study of Efficacy of a DBM-rifampicin Composite Graft in Healing of Segmental Radial Defect in Rabbits
- VernacularTitle:异体脱钙骨基质-利福平明胶复合材料治疗修复兔桡骨缺损的实验研究
- Author:
Huicheng FENG
;
Ming HU
;
Yuanzheng MA
;
Hongwei LI
- Publication Type:Journal Article
- Keywords:
decalcified bone matrix, rifampicin, anti-tuberculosis, composite graft
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(6):529-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the antibiotics release characteristic and osteogenesis ability of anti-tuberculosis composite graft by observing the healing effect of segmental radial defect in rabbits.Methods Rabbit decalcified bone matrix(DBM) was made under the method of Urist and was combined with rifampicin-gelatin solution. The antibiotics release characteristics were observed by PBS release test in vitro and K-B disc diffusion test in vivo. The osteogenesis ability was measured by critical radius bone defect of rabbit.Results It was detected in release test that the antibiotic releasing time could maintain at least 28 days in vivo and in vitro and the release ratio was 87%. The rabbit critical radius bone defect could be repaired by this anti-tuberculosis composite graft perfectly.Conclusion Good antibiotics release characteristics and bone formation ability showed during this anti-tuberculosis composite graft and it definitely could be used widely in further clinics.
