Effects of Repetitive Transcranial Magnetic Stimulation on Locomotor Outcome of Spinal Cord Injured Rats
- VernacularTitle:重复经颅磁刺激对脊髓运动功能恢复的影响及其机制的实验研究
- Author:
Xin ZHANG
;
Jianjun LI
;
Xiaolin HUO
;
Hong DAI
;
Lidong PAN
- Publication Type:Journal Article
- Keywords:
spinal cord injury, repetitive transcranial magnetic stimulation(rTMS), growth associated protein 43(GAP43), 5-hydroxytryptamine(5-HT)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of repetitive transcranial magnetic stimulation(rTMS)on spinal cord injured rats.Methods Weight-drop spinal cord injury model was made at thoracic 10 segments with NYU impactor device.Stimulated group received daily superthreshold rTMS continued for 4 weeks.BBB locomotor scores were recorded weekly.Growth associated protein 43(GAP43)and 5-hydroxytryptamine(5-HT)were detected with immunofluorescence staining in the area of rostral and caudal to the lesion.Results The BBB scores in stimulation group improved compared with that in the control(P<0.01).GAP43 and 5-HT markers increased in the stimulation group(P<0.01),and they increased in the rostral than in the caudal areas(P<0.01).Conclusion rTMS can improve the locomotor function of incomplete spinal cord injury rats,which may result from the increase of expression of GAP43 and 5-HT.
