Construction of albumin corona and its application in pharmaceutical preparation
10.11665/j.issn.1000-5048.20220427003
- VernacularTitle:白蛋白冠的构建及其在药物制剂研究中的应用
- Author:
Qinglin YANG
1
;
Leiqiang HAN
;
Yongjun Leiqiang
;
Na ZHANG
Author Information
1. 山东大学药学院天然产物化学生物学教育部重点实验室
- Publication Type:Journal Article
- Keywords:
protein corona;
albumin corona;
drug delivery;
surface modification;
specific adsorption of albumin
- From:
Journal of China Pharmaceutical University
2023;54(1):49-55
- CountryChina
- Language:Chinese
-
Abstract:
Protein corona is a protein layer that adsorbs on the surface after nonspecific interactions between nanoparticles and plasma proteins.In recent years, studies have shown that modification of specific plasma proteins on the surface of nanoparticles to construct protein corona can prolong the blood half-life of nanoparticles and promote the targeted delivery of nanoparticles, which has attracted widespread attention to the study of drug-carrying systems, among which, albumin corona, the most abundant protein in blood, is the most widely studied.Based on the above, this paper systematically summarized the method of constructing albumin corona and its application in the research on pharmaceutical preparations, in order to provide reference for the construction of albumin corona in the process of drug preparation.
