Nucleic acid drug delivery strategies without the lysosomal pathway
10.11665/j.issn.1000-5048.20221115001
- VernacularTitle:跨越溶酶体途径的核酸药物递送策略
- Author:
Meng OU
1
;
Yinyu YAN
;
Yu MA
;
Jin HONG
;
Ya DING
Author Information
1. 中国药科大学药学院药物分析系
- Publication Type:Journal Article
- Keywords:
nucleic acid drugs;
cytosolic delivery;
lysosome pathway;
membrane translocation;
membrane fusion
- From:
Journal of China Pharmaceutical University
2023;54(1):34-48
- CountryChina
- Language:Chinese
-
Abstract:
By regulating gene expression, nucleic acid drugs functioning in the cytoplasm or nucleus are of great significance in the treatment of acquired or inherited diseases and vaccine development.A variety of nucleic acid delivery vectors currently developed are suffering from low transfection efficiency due to endosome/lysosome entrapment.This paper introduces and summarizes the nucleic acid delivery strategies that bypass the endosomal/lysosomal pathway, including membrane translocation, membrane fusion, receptor/transporter-mediated non-endocytic uptake and caveolae-mediated endocytosis, and discusses the problems and challenges facing such strategies, aiming to facilitate the development of intracellular delivery of nucleic acid drugs bypassing lysosomal pathway.
