Research progress of bio-metal organic frameworks in drug delivery system
10.11665/j.issn.1000-5048.20221111003
- VernacularTitle:生物金属有机框架在药物递送系统中的研究进展
- Author:
Jiayu YU
1
;
Zezhi LIN
;
Wei CAO
;
Jianjun ZHANG
;
Yuanfeng WEI
;
Yuan GAO
;
Shuai QIAN
Author Information
1. 中国药科大学药学院
- Publication Type:Journal Article
- Keywords:
metal organic frameworks;
biocompatibility;
synthesis;
drug loading;
drug delivery system
- From:
Journal of China Pharmaceutical University
2023;54(1):23-33
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, bio-metal organic frameworks (Bio-MOFs) synthesized with biocompatible ligands have been widely investigated as a potential drug delivery carrier due to their large specific surface area and porosity, rich host-guest intermolecular interactions, and good biocompatibility.In this review, we summarized the design methods of Bio-MOFs including structural and toxic factors, as well as a variety of drug loading methods including click chemistry, with particular focus on recent research advances in Bio-MOFs for pulmonary drug delivery systems, improving pharmaceutical properties of drugs, sustained and controlled drug release, stimulation response and targeted drug delivery systems.Finally, we summarized the bottlenecks that constrain the development of Bio-MOFs in clinical studies of actual pharmaceutical formulations and their future directions for approved formulations, aiming to provide some theoretical reference for promoting the application of Bio-MOFs in drug delivery systems.
