Research progress of tumor immunomodulation strategies based on nanodrug delivery system
10.11665/j.issn.1000-5048.2023021501
- VernacularTitle:基于纳米药物递送载体的肿瘤免疫调控策略研究进展
- Author:
Yanhong LIU
1
;
Liqing CHEN
;
Xintong ZHANG
;
Zhonghao GAO
;
Wei HUANG
Author Information
1. 中国医学科学院北京协和医学院药物研究所药物制剂研究室
- Publication Type:Journal Article
- Keywords:
tumour immunotherapy;
nanodrug delivery systems;
tumour immune microenvironment
- From:
Journal of China Pharmaceutical University
2023;54(1):5-14
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunotherapy is a therapeutic modality that uses immunological principles and methods to activate and enhance the body''s immune system to generate immune response for the removal of tumour cells. Many new immunotherapeutic agents have demonstrated effective anti-tumour capabilities, yet their clinical use is challenging due to the complex mechanisms of tumour immune escape. Meanwhile, these drugs would accumulate in different tissues and organs in the human body and be unable to achieve precise and specific targeting therapeutic effects, resulting in serious immune-related adverse effects, which greatly hinders the clinical potential of immunotherapy.Nanodrug delivery systems can deliver immunotherapeutic drugs to target tissues or specific immune cells precisely, thereby enhancing immune effects and reducing side effects.This paper reviews the research progress of nanodrug delivery systems in tumour immunotherapy in recent years based on the regulatory mechanism of the anti-tumour immune response, with a prospect of the challenges and development in this field.
