Refractory and super refractory status epilepticus in the Philippines: A 10-year retrospective study.
- Author:
Liz Edenberg P. Quiles
;
Marc Laurence C. Fernandez
- Publication Type:Journal Article
- Keywords:
refractory status epilepticus;
super refractory status epilepticus;
- MeSH:
Status Epilepticus;
Philippines;
Seizures
- From:
Philippine Journal of Neurology
2019;22(1):41-49
- CountryPhilippines
- Language:English
-
Abstract:
PURPOSE:Super refractory status epilepticus (SRSE) is an uncommon, but important clinical problem with high
morbidity and mortality. Studies concerning SRSE has been limited and there are no existing Philippine
data. The study aims to determine the status of Refractory (RSE) and SRSE within a 10-year period in a
Tertiary Hospital.
METHODS:This is a retrospective study of adult patients with prolonged seizures admitted at The Medical City,
Philippines from January 2009- July 2018. Multinomial Logistic Regression was used to assess probability
of good or poor outcome. Significant Correlation is defined by P value of <0.05.
RESULTS:The Incidence of RSE is as high as 38% (n=64) and 35% (n=58) for SRSE. Mortality rate is 39.1% in RSE
and 62.1% in SRSE. Poor functional outcome is observed in RSE and SRSE wherein the majority was Alive
Dependent. Significant factor increasing likelihood of being Alive Dependent is the absence of Arrest.
CONCLUSION:Factors associated with likelihood of being alive and independent includes Status Epilepticus and younger
age therefore aggressive seizure control to prevent progression to SRSE will give higher likelihood of good
functional outcome and elderly patients warrant closer and more adept seizure control for better
functional outcome.
- Full text:Refractory and super refractory status epilepticus.pdf
