Clinico-radiologic profile of a dorsal variant of posterior cortical atrophy in a 55- year old female.
- Author:
Jeryl T. Yu
;
Jacqueline Dominguez
;
Ma. Socorro Martinez
;
Franz Marie Cruz
;
Ron Pilotin
- Publication Type:Journal Article
- Keywords:
Posterior Cortical Atrophy;
Alzheimer’s Disease;
simultagnosia;
ApoE polymorphism;
amyloid;
Dorsal variant;
FDG-PET;
- MeSH:
Neuropsychological Tests
- From:
Philippine Journal of Neurology
2019;22(1):15-21
- CountryPhilippines
- Language:English
-
Abstract:
Posterior Cortical Atrophy is a group of neurodegenerative disorders characterized by early, prominent
and progressive impairment of visuospatial and visuoperceptual functions in the context of relatively
preserved memory and insight in the early phases. Initial visual symptoms are vague, compelling patients
to seek ophthalmologic consult. They present with simultagnosia and spatial disorientation, which are
often missed by routine ophthalmologic and neurologic exams, causing delay in diagnosis. As the disease
progresses, Posterior Cortical Atrophy ultimately leads to a more diffuse pattern of cognitive dysfunction.
The underlying pathology is believed to be Alzheimer’s Disease and a greater level of amyloid plaques is
correlated with earlier clinical symptoms of Posterior Cortical Atrophy. The clinical features of reported
cases are heterogenous, leading to a classification of different variants and underlying pathologies. We
report the serial clinical, cognitive and imaging data of a variant of Posterior Cortical Atrophy primarily
affecting the dorsal stream.
- Full text:Clinico-radiologic profile.pdf
