Research progress on biomarkers for pneumoconiosis
- Author:
YANXin hua HUYuan yuan TIANYan ge
- Publication Type:Journal Article
- Keywords:
Pneumoconiosis;
Biomarker;
Epithelialcellinjury;
Inflammation;
Oxidativestress;
Fibrosis;
Non codingRNA
- From:
China Occupational Medicine
2022;51(03):355-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: -
Well characteristic biomarkers are helpful for understanding the disease condition of patients with occupational
pneumoconiosisand predictthediseaseevolution.Currently,related biomarkersarewidelystudied and theyinclude:epithelial
cell injury related biomarkers such as salivary glycochain antigen, Clara cell protein and surfactant protein; inflammatory
- -
response related biomarkers such as interleukin, tumor necrosis factor α, chemokine, high mobility group protein 1 and
- -
L selectin; oxidative stress related biomarkers such as superoxide dismutase, glutathione, malondialdehyde, heme oxygenase 1
and lactate dehydrogenase; pulmonary fibrosis related biomarkers such as matrix metalloproteinases and transforming growth
- - - - -
factor β; non coding RNA such as miR 19a, miR 29 and miR 146a, et al. These biomarkers are helpful to understand the
pathogenesisofoccupationalpneumoconiosisandguidethediagnosis,treatmentandprognosis.However,moreresearchneedsto-bedoneontherepeatabilitytestofbiomarkers,combinedapplicationandtheminingofnoncodingRNAastargetsfordisease
diagnosisandtreatment.
