Application of mass spectrometry in occupational health
- Author:
LIUMeng meng XIAYi ping LIUBao feng ZENGQiang
- Publication Type:Journal Article
- Keywords:
MassspectrometryOccupationalhealthWorkplaceBiomarkerMetabolomicsProteomics
- From:
China Occupational Medicine
2022;51(03):350-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: ，
Mass spectrometry technology has the advantages of high sensitivity high resolution and low detection limit. It is
- ，
widely used in the field of occupational health for rapid on site detection and accurate laboratory detection of workplace air
， ，
biomarkermonitoring metabolomicsandproteomics andmore.Massspectrometrytechniquehasirreplaceableadvantagesover--
traditional technical means. It is applied to the rapid detection of workplace occupational disease inductive factors and
，
laboratoryevaluation.Analysisontheaccuratedetectioncaneffectivelyidentifiedthekeyfactors.However theexistingstudies
，
are mostly limited in basic research with few in the promotion and application in laboratory. The current occupational health
researchhasonlyeightnationalstandardsrelatedtomassspectrometry.Itisurgenttoissuemorenationalstandardsusingmass-，spectrometryforpoisondetection.Massspectrometryisappliedtothehighthroughputanalysisofbiomarkersmetabolitesand，，proteinswhichcanbeusedtoevaluatetheextentofhumanexposureandpossiblepotentialhealtheffects.Howeverthe，existingstudiesaremostlyconfinedtothelaboratoryandthereisalackoffurtherconfirmationofpossiblebiomarkers.Atthe，sametimetheexistingmassspectrometryanalysismethodsaremostlyusedincombinationwithspectralandchromatographic，-，methodswhichhavesomelimitationsintherapidinsituanalysisoftoxicants.Thereforeanopenatmosphericpressureion，--sourcecanbeintroducedtoachievedirectonlineandinsituanalysisofsamples.
