Research progress on the relationship between noncoding region of singlenucleotide polymorphism and noise-induced hearing loss
- Author:
CHENYu quan LIUYi min
- Publication Type:Journal Article
- Keywords:
Noise Hearing loss Non coding region Single nucleotide polymorphism MicroRNA Genes CorrelationResearchprogress
- From:
China Occupational Medicine
2022;51(03):337-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: - （ ） ，
Noise induced hearing loss NIHL is a hearing disorder that seriously harms the health of workers and it is a
（ ）
complex disease caused by environmental and genetic factors. Single nucleotide polymorphism SNP is the most common
， （ ）
genetic variation which is associated with the occurrence and development of NIHL. MicroRNA miRNA is a kind of small
- - ， -
non codingsingle strandedRNA whichishighlyexpressedinthecochleaandregulatesgenesbybindingtothe3′ untranslated
（ ） -
regionoftargetmessengerRNA mRNA .SNPofmiRNA isthemostcommongeneticvariation.SNPinthenon codingregion，
participates in gene expression regulation and phenotype generation by leading to abnormal miRNA recruitment thereby，
affecting the occurrence and development of NIHL. The genetic susceptibility genes of NIHL include oxidative stress genes
-
singlegenedeafnessgenesandheatshockproteingenes.TheSNPinthenon codingregionisassociatedwiththesusceptibility，
of NIHL. miRNA SNP has been confirmed to be involved in the development of NIHL but the correlation between different
miRNASNPandNIHLisdifferent.SNPaffectsthesusceptibilityofNIHLbyaffectingtheexpressionandfunctionofmiRNA.
