Correlation analysis of glucose and lipid metabolism in elderly patients with Helicobacter pylori infection complicated with metabolic syndrome
10.3969/j.issn.1006-2483.2023.02.030
- VernacularTitle:老年幽门螺旋杆菌感染合并代谢综合征患者糖血脂代谢的相关性分析
- Author:
Shumin ZHOU
1
;
Xinyue ZHANG
1
;
Yiman LI
1
Author Information
1. Department of laboratory , Bazhong Central Hospital , Bazhong , Sichuan 636000 , China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori infection;
Metabolic syndrome;
Glucolipid metabolism
- From:
Journal of Public Health and Preventive Medicine
2023;34(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of glucose and blood lipid metabolism in elderly patients with Helicobacter pylori (Hp) infection complicated with metabolic syndrome (MS), and to provide theoretical basis for clinical diagnosis and treatment of MS patients. Methods A total of 176 elderly MS patients treated in our hospital from February 2020 to February 2021 were selected. Uremic [13C] tablet breath test kit was used to determine Hp infection. According to Hp infection, they were divided into Hp positive group (n=59) and Hp negative group (n=117). Glucose metabolism indexes (FBG, 2hPG, HbA1c, FINS) and serum lipid metabolism indexes (TC, HDL-C, LDL-C) were determined in all subjects. Risk factors of Hp infection in MS patients were analyzed by multivariate logistic regression. Pearson correlation analysis was conducted between sreum LDL-C, HbA1c and FINS levels and DOB value in MS patients. Results The levels of FBG, 2hPG, HbA1c, FINS and LDL-C in Hp positive group were significantly higher than those in Hp negative group (P<0.05). There was no significant difference in LDL-C and TC between Hp positive group and Hp negative group (P>0.05). It showed that LDL-C, HbA1c and FINS were independent risk factors for Hp infection in MS patients (P<0.05). Pearson correlation analysis showed that There was a positive correlation between DOB and LDL-C, HbA1c and FINS levels in MS patients (r=0.475,0.512,0.459,P<0.05). Conclusion Hp infection can affect glucose and lipid metabolism in elderly MS patients, and there is a close relationship between Hp infection and ldL-C, HbA1c and FINS levels in elderly MS patients.
