Determination of 10 organophosphorus flame retardants in drinking water by On-line SPE-UPLC-MS/MS
10.3969/j.issn.1006-2483.2023.02.010
- VernacularTitle:在线固相萃取-超高效液相色谱-串联质谱测定饮用水中10种有机磷阻燃剂
- Author:
Yi-chen CHEN
1
,
2
;
Lei ZHENG
3
;
Wei MIN
3
;
Ming ZHAN
3
;
Yijing ZHAO
3
Author Information
1. Fudan University School of Public Health , Shanghai 200032 , China
2. Shanghai Pudong New Area Center for Disease Control and Prevention , Fudan University Pudong Institute of Preventive Medicine , Pudong New Area , Shanghai 200136 , China
3. Pudong District Center for Disease Control and Prevention , Shanghai 200136 , China
- Publication Type:Journal Article
- Keywords:
On-line solid phase extraction coupled with high performance liquid chromatography-tandem mass spectrometrye;
Organophosphorus flame retardants;
Drinking water
- From:
Journal of Public Health and Preventive Medicine
2023;34(2):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for the determination of 10 organophosphorus flame retardants in drinking water by on-line solid phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry (On-line SPE-UPLC-MS/MS). Methods After adding the internal standard, the water sample was filtered by Millipore filtration, and then concentrated and detected by Online SPE-UPLC-MS/MS. Samples were concentrated by C8 SPE column and separated by C18 column with acetonitrile-water-formic acid as the mobile phases gradient elution，and were detected by multiple reaction monitoring (MRM) acquisition under anion mode. Results The 10 organophosphorus flame retardants all displayed good linear relationships within a certain range of concentrations, with the correlation coefficients being more than 0.990. The method detection limits were 0.60-5.50 ng/L, and the spiked recoveries of low, medium and high concentrations were 64%-106% , 83%-104% and 85%-99%, respectively. Conclusion The method is simple, sensitive, rapid, accurate and reliable, so it is applicable for the determination of 10 organophosphorus flame retardants in drinking water.
