Variation in oxidative injury markers in workers with occupationalnoise-induced hearing loss
- Author:
JIFang ZHANGJian DINGXiao wen RONGLi LIJue
- Publication Type:Journal Article
- Keywords:
Noise Hearingloss Oxidativedamage GlutathioneS transferase Superoxidedismutase Catalase Biomarker
- From:
China Occupational Medicine
2022;51(03):292-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Objective -
To explore the changes of oxidative damage indicators in workers with occupational noise induced
（ ）， Methods
hearingloss ONHL andtoscreenpossiblebiomarkersofONHL. Atotalof288maleworkersexposedtonoisein
a large machinery maintenance enterprise were selected as the research subjects using the method of judgment sampling. After
，
pure tone hearing threshold test they were divided into hearing loss group and normal hearing group according to the hearing
∶ ， ， ，
loss and 1 1 pairing design of type of work age length of service with 144 people in each group. The activities of total
（ - ）， - （ - ）， （ - ），
superoxidedismutase T SOD copper zincsuperoxidedismutase CuZn SOD manganesesuperoxidedismutase Mn SOD
- （ ） （ ） Results
glutathione S transferase GST and catalase CAT in serum of workers of the two groups were measured. The
， - ， -
activitiesofGST T SOD Mn SOD and CAT in workersofthe hearing lossgroup were lowerthan those in the normalhearing
（ P< ） ∶
group all 0.05 . The 1 1 logistic regression analysis of paired conditions showed that there was an association between
， - ， （ P< ）
ONHL and activities of GST Mn SOD and CAT in serum all 0.05 after controlling the effects of smoking and drinking.
， - ， -
ThehighertheactivitiesofGST Mn SODandCAT thelowertheriskofONHL.TheactivityofCuZn SODwasnotassociated
（P ）Conclusion ， -
withONHL >0.05 . TheactivitiesofserumantioxidantenzymessuchasGST Mn SODandCATarerelatedto
ONHL.ThoseantioxidantenzymescanbeusedaseffectivebiomarkersforONHLworkers.
