Huaxian Sanjie compound granule improves silicosis fibrosis in rats throughPI3K/Akt/NF-κB signaling pathway
- Author:
YINQin YANGJie FANCun yu MEIFeng YUWei LIJuan YILi ping YUYi han LINGRui jie
- Publication Type:Journal Article
- Keywords:
HuaxianSanjiecompoundgranuleSilicosisPulmonaryfibrosisInterleukin6Transforminggrowthfactorβ-；；；PI3K/Akt/NFκBSignalpathwayCollagentypeⅠRat
- From:
China Occupational Medicine
2022;51(03):272-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Objective
To study the effect and mechanism of Huaxian Sanjie compound granule on silicosis fibrosis in rats.
Methods
The specific pathogen free male SD rats were randomly divided into control group, silicosis model group and
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interventiongroup,withsixratsineachgroup.Disposableventilatorcombinedwithnon exposedintratrachealdripwasused,the
ratsinthesilicosismodelgroupandinterventiongroupweretreatedwith 1.0mLsilica suspensionwithamassconcentrationof
50.0 g/L to establish silicon dust rat model, while the rats in the control group were treated with equal volume of 0.9% sodium
chloride solution. After 24 hours of dust exposure, the rats in the intervention group were given 10 mL/kg body weight of
Huaxian Sanjie compound granule suspension with a mass concentration of 212.5 g/L by gavage, while the rats in the control
group and silicosis model group were given the same amount of 0.9% sodium chloride solution, once a day. Three rats in each
groupweresacrificedonthe14thand28thday,respectively,andtheirlungtissueswereseparatedforpathologicalexamination.----Thelevelsofinterleukin6(IL6)andtransforminggrowthfactorβ
