Electrophysiological and Morphological Changes After Intravitreal Bevacizumab Injection with Macular Edema or Choroidal Neovascularization.
10.3341/jkos.2009.50.12.1824
- Author:
Hyun Joon LEE
1
;
Joo Youn PARK
;
Young Hoon OHN
Author Information
1. Department of Ophthalmology, Soonchunhyang University College of Medicine, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Choroidal neovascularization;
Intravitreal Bevacizumab injection;
Macular edema;
Multifocal electroretinogram
- MeSH:
Antibodies, Monoclonal, Humanized;
Choroid;
Choroidal Neovascularization;
Diabetic Retinopathy;
Eye;
Humans;
Macular Degeneration;
Macular Edema;
Retinal Vein Occlusion;
Tomography, Optical Coherence;
Visual Acuity;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2009;50(12):1824-1830
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the functional and anatomical statuses of macula with multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) for the treatment of patients with macular edema after intravitreal bevacizumab injection. METHODS: Patients were injected with intravitreal bevacizumab (1.875 mg/0.075 ml) for macular edema with choroidal neovascularization (CNV), diabetic retinopathy and retinal vein occlusion. RESULTS: A total of 120 eyes (96 patients) were diagnosed with diabetic retinopathy, CNV with age-related macular degeneration and retinal vein occlusion. Visual acuity improved from logMAR 0.85+/-0.39 to 0.54+/-0.38 after intravitreal bevacizumab injection. The implicit time of P1 and N2 in mfERG decreased, and the amplitude of P1 showed a statistically significant increase. Central macular thickness decreased from 374.4+/-135.2 micrometer to 249.0+/-72.0 micrometer. CONCLUSIONS: After intravitreal bevacizumab injection, functional and anatomical statuses of mfERG and OCT improved. This study demonstrates a method for utilizing mfERG to assess the effectiveness of treatments such as bevacizumab.
